Prefrontal Glutamate Neurotransmission in PTSD: A Novel Approach to Estimate Synaptic Strength in Vivo in Humans.
Lynnette A AverillLihong JiangPrerana PurohitAnastasia CoppoliChristopher L AverillJeremy RoscoeBenjamin KelmendiHenk M De FeyterRobin A de GraafRalitza GueorguievaGerard SanacoraJohn H KrystalDouglas L RothmanGraeme F MasonChadi G AbdallahPublished in: Chronic stress (Thousand Oaks, Calif.) (2022)
C-acetate MRS were established. Patients with PTSD were found to have reduced prefrontal glutamatergic synaptic strength. These findings suggest that reduced glutamatergic synaptic strength may contribute to the pathophysiology of PTSD and could be targeted by new treatments.