APOE effects on regional tau in preclinical Alzheimer's disease.

Christina B YoungEmily JohnsGabriel KennedyMichael E BelloyPhilip S InselMichael D GreiciusReisa A SperlingKeith A JohnsonKathleen L PostonElizabeth C Morminonull nullnull null

Published in: Molecular neurodegeneration (2023)

APOE influences early regional tau PET burden, above and beyond effects related to cross-sectional amyloid PET burden. Therapeutic strategies targeting underlying mechanisms related to APOE may modify tau accumulation among Aβ+ individuals.

Keyphrases

cognitive decline
cross sectional
cerebrospinal fluid
high fat diet
computed tomography
positron emission tomography
pet ct
mild cognitive impairment
pet imaging
risk factors
type diabetes
cell therapy
adipose tissue
insulin resistance
skeletal muscle
bone marrow