Pharmacokinetic Modelling of Human Recombinant Protein, p75ECD-Fc: A Novel Therapeutic Approach for Treatment of Alzheimer's Disease, in Serum and Tissue of Sprague Dawley Rats.

Sally Kelliny Larisa Bobrovskaya Xin-Fu Zhou Richard N Upton

Published in: European journal of drug metabolism and pharmacokinetics (2021)

This is the first report of a pharmacokinetic model for p75ECD-Fc and these results may facilitate the ongoing development of p75ECD-Fc and translation to clinical studies.

Keyphrases

endothelial cells
cognitive decline
induced pluripotent stem cells
pluripotent stem cells
protein protein
amino acid
binding protein
replacement therapy