Participation of osteoclastogenic factors in immunopathogenesis of human chronic periapical lesions.
S C L T SantosL A CoutoJ M FonsecaF C A XavierA C L FigueiredoV S FreitasR A FreitasJ N SantosÁguida Cristina Gomes HenriquesPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2017)
This study demonstrated the participation of RANKL, TNF-α, IL-33, cathepsin K, and OPG in the development of RCs and PGs, with emphasis on the highest immunoreactivity of cathepsin in RCs and TNF-α and OPG in PGs. OPG possibly determines the slower growth of PGs compared to RCs.