Patent Foramen Ovale Closure in Older Patients With Stroke: Patient Selection for Trial Feasibility.
Andy Y WangPeter M RothwellJason NelsonJeffrey L SaverScott E KasnerJohn CarrollJean-Louis MasGeneviève DerumeauxGilles ChatellierAnthony J FurlanHoward C HerrmannPeter JüniJong S KimBenjamin KoethePil H LeeBenedicte LefebvreHeinrich P MattleBernhard MeierMark ReismanRichard W SmallingLars SondergaardJae-Kwan SongEmanuele Di AngelantonioMarco R Di TullioMitchell S V ElkindShunichi HommaCheryl JaigobinPatrik MichelMarie-Luise MonoKrassen NedeltchevFederica PapettiJoaquin SerenaChristian WeimarLinxin LiSara MazzuccoLouise E SilverDavid van KlaverenDavid E ThalerDavid M KentPublished in: Neurology (2024)
Based on our projections, anticipated effect sizes in older patients with high-risk features make a trial in these subjects feasible. With lengthening life expectancy in almost all regions of the world, the utility of PFO closure in older adults is increasingly important to explore.