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Aim2 Couples With Ube2i for Sumoylation-Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus.

Ailing LuShuxian WuJunling NiuMengmeng CuiMengdan ChenWilliam L ClappBetsy J BarnesGuang-Xun Meng
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
The present study demonstrates a critical role for Aim2 in an optimal Ube2i-mediated sumoylation-based suppression of type I IFN generation and development of SLE. As such, the Aim2-Ube2i axis can thus be a novel target for intervention in SLE.
Keyphrases
  • systemic lupus erythematosus
  • disease activity
  • randomized controlled trial
  • immune response
  • rheumatoid arthritis
  • genome wide
  • gene expression
  • dna methylation