Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis.

Peter J O'ShaughnessyRod T MitchellAna MonteiroLaura O'HaraLyndsey CruickshanksHedi Claahsen-van der GrintenPamela BrownMargaret AbelLee B Smith

Published in: BMC developmental biology (2019)

This study shows that in the mouse the androgen receptor is required both to prevent development of testicular cells with adrenal characteristics and to ensure development of an adult Leydig cell phenotype.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
poor prognosis
signaling pathway
cell death
cell proliferation
long non coding rna
bone marrow
binding protein