Ursolic acid improves the indoxyl sulfate-induced impairment of mitochondrial biogenesis in C2C12 cells.

Yutaro Sasaki Akiko Kojima-Yuasa Hinako Tadano Ayaka Mizuno Atsushi Kon Toshio Norikura

Published in: Nutrition research and practice (2021)

Our results indicated that UA improves the IS-induced impairment of mitochondrial biogenesis by affecting differentiation, ATP levels, and IL-6 secretion in C2C12 cells. Therefore, UA could be a novel therapeutic agent for CKD-induced muscle dysfunction.

Keyphrases

oxidative stress
induced apoptosis
diabetic rats
high glucose
chronic kidney disease
endothelial cells
endoplasmic reticulum stress
cell death
cell proliferation