G-CSF rescue of FOLFIRINOX-induced neutropenia leads to systemic immune suppression in mice and humans.
Victoire Cardot-RuffinoNaima BollenrucherLuisa DeliusS Jennifer WangLauren K BraisJoshua RemlandC Elizabeth KehelerKeri M SullivanThomas A AbramsLeah H BillerPeter C EnzingerNadine J McClearyAnuj K PatelDouglas A RubinsonBenjamin SchlechterSarah SlaterMatthew B YurgelunJames M ClearyKimberly PerezMichael DouganKimmie NgBrian M WolpinHarshabad SinghStephanie K DouganPublished in: Journal for immunotherapy of cancer (2023)
Pegfilgrastim use contributes to immune suppression in both humans and mice with pancreatic cancer. These results suggest that use of recombinant G-CSF as supportive care, while critically important for mitigating neutropenia, may complicate efforts to induce antitumor immunity.