PET imaging of nectin-4: A promising tool for personalized/precision oncology.
Dawei JiangXiaoli LanWeibo CaiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
In a recent study, the authors developed a nectin-4-targeting bicyclic peptide-based radiotracer, 68Ga-N188, for PET imaging of advanced urothelial cancer. Preclinical investigation and first-in-human study in 14 patients demonstrated excellent specificity and sensitivity of 68Ga-N188 in detecting metastases. These promising results support 68Ga-N188 as a companion diagnostic for future personalized cancer therapy.
Keyphrases
- pet imaging
- pet ct
- cancer therapy
- positron emission tomography
- end stage renal disease
- endothelial cells
- chronic kidney disease
- ejection fraction
- palliative care
- squamous cell carcinoma
- high grade
- stem cells
- bone marrow
- papillary thyroid
- peritoneal dialysis
- patient reported outcomes
- cell therapy
- current status
- pluripotent stem cells