Genomic landscape and mutational impacts of recurrently mutated genes in cancers.
Baolin LiuFei-Fei HuQiong ZhangHui HuZheng YeQin TangAn-Yuan GuoPublished in: Molecular genetics & genomic medicine (2018)
Through the functional analysis of RMGs, we found that six signaling pathways were disrupted in most cancer types and that energy metabolism was abnormal in tumors. The results also revealed a strong correlation between recurrently mutated genes from MUC family and human survival. In addition, gene expression and survival prognosis were associated with different mutation types of RMGs.
Keyphrases
- gene expression
- genome wide
- endothelial cells
- dna methylation
- signaling pathway
- papillary thyroid
- bioinformatics analysis
- free survival
- genome wide identification
- squamous cell
- copy number
- childhood cancer
- pluripotent stem cells
- induced pluripotent stem cells
- squamous cell carcinoma
- cell proliferation
- lymph node metastasis
- endoplasmic reticulum stress