Oedema on STIR modified the effect of amoxicillin as treatment for chronic low back pain with Modic changes-subgroup analysis of a randomized trial.

Per Martin KristoffersenLars C H BråtenNils VettiLars GrøvleChristian HellumKjersti StorheimJohn-Anker ZwartJörg AssmusAnsgar Espeland

Published in: European radiology (2020)

• In the primary analysis of the AIM trial, the effect of amoxicillin in patients with chronic low back pain and type 1 or 2 MCs did not reach the predefined cut-off for clinical importance. • In the present MRI subgroup analysis of AIM, predefined subgroups with abundant MC-related oedema on STIR reported an effect of amoxicillin. • This finding requires replication and further support.

Keyphrases

phase iii
study protocol
contrast enhanced
open label
randomized controlled trial
computed tomography