Regulation of connective tissue growth factor expression by miR-133b for the treatment of renal interstitial fibrosis in aged mice with unilateral ureteral obstruction.

Dan CaoYuan WangYingjie ZhangYinping ZhangQi HuangZhong YinGuangyan CaiXiangmei ChenXuefeng Sun

Published in: Stem cell research & therapy (2021)

miR-133b exerted targeted inhibitory effects on CTGF expression, which consequently reduced TGF-β1-induced EMT of HK2 cells and renal interstitial fibrosis in aged mice with UUO.

Keyphrases

growth factor
poor prognosis
high glucose
induced apoptosis
high fat diet induced
binding protein
diabetic rats
long non coding rna
transforming growth factor
cancer therapy
adipose tissue
endoplasmic reticulum stress
endothelial cells
drug delivery
wild type
cell proliferation
insulin resistance
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