Murici ( Byrsonima crassifolia (L.) Kunth and verbascifolia (L.)) and Tapereba ( Spondias mombin ) Improve Hepatic and Inflammatory Biomarkers in High-Fat-Diet Rats.
Vanessa Rosse de SouzaThuane Passos Barbosa LimaTeresa Palmiciano BedêSabrina Baptista Alves FariaRenata AlvesAlana LouzadaBianca Portugal Tavares de MoraesAdriana Ribeiro SilvaCassiano Felippe Gonçalves-de-AlbuquerqueVilma Blondet de AzeredoAnderson Junger TeodoroPublished in: Foods (Basel, Switzerland) (2023)
The present study investigated the effects of murici and tapereba on improving hepatic and inflammatory biomarkers in high-fat-diet rats. Female Wistar rats were divided into five groups ( n = 10/group): control (CON), high-fat diet (HF), murici drink + high-fat diet (Mu-HF), tapereba drink + high-fat diet (Tap-HF), and murici and tapereba blend drink + high-fat diet (MT-HF). Drinks were offered daily for 60 days, following which body and liver weights, hepatosomatic indexes, serum parameters, inflammatory profile, and antioxidant activity (DPPH and ORAC) were analyzed. The cell death of hepatic cells was evaluated using flow cytometry. It was observed that weight gain was similar among the groups, while glycemia was lower in the MT-HF group. A high-fat diet increased the concentration of cholesterol total, ALT, IL-1β (in plasma and liver), and TNF-α (in the liver), and this was reduced by treatment with the fruit-based beverages. The other evaluated parameters showed no statistically significant difference. Compared to the CON and HF groups, the groups that received the drinks had higher cellular antioxidant activity and reduced oxidative stress, lipid oxidation, and development of pro-inflammatory cytokines, such as IL-1β. A high-fat diet induced higher cell death in hepatic tissue, which was prevented by the murici, tapereba, and the fruit-blend drinks. The consumption of murici, tapereba, and fruit-blend-based beverages showed beneficial effects on liver metabolism; therefore, they may serve as a nutritional approach for preventing and treating non-alcoholic liver disease.
Keyphrases
- high fat diet
- insulin resistance
- adipose tissue
- cell death
- oxidative stress
- weight gain
- high fat diet induced
- acute heart failure
- flow cytometry
- cell cycle arrest
- body mass index
- induced apoptosis
- rheumatoid arthritis
- type diabetes
- heart failure
- high resolution
- dna damage
- fatty acid
- nitric oxide
- cell proliferation
- birth weight
- mass spectrometry
- diabetic rats
- atomic force microscopy
- anti inflammatory