DNA-PK Inhibition and Radiation Promote Antitumoral Immunity through RNA Polymerase III in Pancreatic Cancer.
Weiwei WangMatthew T McMillanXinyi ZhaoZhuwen WangLong JiangDavid KarnakFatima LimaJoshua D ParselsLeslie A ParselsTheodore S LawrenceTimothy L FrankelMeredith A MorganMichael D GreenQiang ZhangPublished in: Molecular cancer research : MCR (2022)
Our work nominates a novel therapeutic strategy as well as its cellular mechanisms pertinent for future clinical trials combining M3814, radiation, and anti-PD-L1 antibody in patients with pancreatic cancer.