Multiple treatments with human embryonic stem cell-derived mesenchymal progenitor cells preserved the fertility and ovarian function of perimenopausal mice undergoing natural aging.
Eun-Young ShinSuji JeongJeoung Eun LeeDong Seok JeongDong Keun HanSeok-Ho HongDong Ryul LeePublished in: Stem cell research & therapy (2024)
Multiple introductions of hESC-MPCs could be a useful approach to prevent female reproductive senescence and that these cells are promising sources for cell therapy to postpone the ovarian aging and retain fecundity in perimenopausal women.
Keyphrases
- cell therapy
- stem cells
- endothelial cells
- postmenopausal women
- induced apoptosis
- cell cycle arrest
- mesenchymal stem cells
- polycystic ovary syndrome
- induced pluripotent stem cells
- bone marrow
- dna damage
- high fat diet induced
- pluripotent stem cells
- signaling pathway
- endoplasmic reticulum stress
- adipose tissue
- cell death
- stress induced
- young adults
- wild type
- pregnant women
- metabolic syndrome