SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy.

Kazuhiro FukumuraJulian P VenablesAkila Mayeda

Published in: Molecular & cellular oncology (2021)

The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to various anticancer drugs, SPF45-dependent splicing may play a critical role in multidrug resistance.

Keyphrases

atrial fibrillation
poor prognosis
papillary thyroid
squamous cell carcinoma
young adults
lymph node metastasis