Randomized Placebo-Controlled Trial of Intravenous Immunoglobulin in Autoimmune LGI1/CASPR2 Epilepsy.
Divyanshu DubeyJeffrey BrittonAndrew McKeonAvi GadothAnastasia ZekeridouSebastian A Lopez ChiribogaMichelle F DevineJane H CerhanKatie DunlayJessica SagenMelanie RambergerPatrick WatersSarosh R IraniSean J PittockPublished in: Annals of neurology (2019)
Superiority of IVIG to placebo reached statistical significance for the primary endpoint for all patients and the subset with LGI1-IgG. These results have to be interpreted with the caveat that the study did not reach its originally selected sample size. ANN NEUROL 2020;87:313-323.