EphrinA3 is a key regulator of malignant behaviors and a potential prognostic factor in lung adenocarcinoma.

Ruzetuoheti YiminniyazeXiujuan ZhangNing ZhuJing WangChengwei LiGulinuer WumaierDaibing ZhouJing LiJingwen XiaYouzhi ZhangLiang DongYuanyuan ZhangShengqing Li

Published in: Cancer medicine (2022)

EphrinA3 expression was negatively correlated with prognosis of patients with LUAD. EphrinA3 promoted proliferation, migration, and invasion of LUAD cells. EphrinA3 enhanced the phosphorylation of ERK and AKT, and potentiates EMT and MMP expression in LUAD cells.

Keyphrases

induced apoptosis
signaling pathway
prognostic factors
poor prognosis
cell cycle arrest
cell proliferation
epithelial mesenchymal transition
pi k akt
endoplasmic reticulum stress
cell death
transcription factor
risk assessment
human health
cell migration