Impact of immunotherapy time-of-day infusion on survival and immunologic correlates in patients with metastatic renal cell carcinoma: a multicenter cohort analysis.
Jimmy S PatelYena WooAmber DraperCaroline S JansenJennifer W CarlislePasquale F InnominatoFrancis A LéviLayla DhabaanViraj A MasterMehmet Asim BilenMohammad K KhanMichael C LoweHaydn T KissickZachary S BuchwaldDavid C QianPublished in: Journal for immunotherapy of cancer (2024)
Patients with mRCC may benefit from earlier time-of-day receipt of ICIs. Our findings are consistent with established mechanisms of chrono-immunology, as well as with preceding analogous studies in melanoma and lung cancer. Additional prospective randomized trials are warranted.