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Phytochemical-loaded liposomes for anticancer therapy: an updated review.

Vivek P ChavdaDisha ViholBhavya MehtaDhruvil ShahManan PatelLalitkumar K VoraMiguel Pereira-SilvaAna Cláudia Paiva Santos
Published in: Nanomedicine (London, England) (2022)
The major obstacles observed in current chemotherapy are severe adverse effects, narrow therapeutic indexes and multidrug resistance. Anticancer phytochemicals are extracted and purified from natural plants, providing alternative therapeutic approaches with recognized biomedical benefits. However, poor bioavailability, high dose requirements and non-specific targeting have made those molecules less effective. To tackle those issues, liposomal nanovesicles for phytochemical delivery are taken into consideration for improving the therapeutic effectiveness by increasing transportation across cell barriers and conferring attractive cancer-specific targeting capabilities. In the present review, the liposomal approaches of anticancer phytochemicals are discussed, and recent advances in these formulations applied to cancer phytotherapy are further reviewed by an informed approach.
Keyphrases
  • papillary thyroid
  • high dose
  • cancer therapy
  • drug delivery
  • squamous cell
  • randomized controlled trial
  • single cell
  • systematic review
  • squamous cell carcinoma
  • early onset
  • stem cells
  • childhood cancer
  • young adults