Adipose tissue mitochondrial capacity associates with long-term weight loss success.
R JokinenR Rinnankoski-TuikkaS KayeL SaarinenS HeinonenM MyöhänenE RappouSakari JukarainenA RissanenA PessiaV VelagapudiK A VirtanenE PirinenK H PietiläinenPublished in: International journal of obesity (2005) (2017)
Higher mitochondrial capacity in SAT predicts good long-term WL success. WL does not ameliorate SAT mitochondrial downregulation and based on pathway expression, may paradoxically further reduce it.Data availability:The transcriptomics data generated in this study have been deposited to the Gene Expression Omnibus public repository, accession number GSE103769.
Keyphrases
- gene expression
- oxidative stress
- adipose tissue
- weight loss
- electronic health record
- poor prognosis
- big data
- healthcare
- dna methylation
- bariatric surgery
- cell proliferation
- single cell
- insulin resistance
- mental health
- roux en y gastric bypass
- signaling pathway
- high fat diet
- binding protein
- metabolic syndrome
- deep learning
- data analysis