PD-1/PD-L1 and immune-related gene expression pattern in pediatric malignant brain tumors: clinical correlation with survival data in Korean population.
Kihwan HwangEun Jung KohEun Jin ChoiTae Hee KangJung Ho HanGheeyoung ChoeSung-Hye ParkJennifer Holmes YearleyLakshmanan AnnamalaiWendy BlumenscheinManjiri SatheTerri McClanahanHun JungKyu-Chang WangSeung-Ki KimChae-Yong KimPublished in: Journal of neuro-oncology (2018)
AT/RT, EPN, and HGG showed a relatively higher expression rate of PD-L1 (19-40%). This suggests these tumor types might be good candidates for PD-1 checkpoint blockade. We determined that gene expression may potentially serve as a molecular tool in predicting which patients will respond to immunotherapy. Further investigation is required to better understand the predictive and prognostic role of PD-L1 in pediatric brain tumors.