Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars.
Panu K LuukkonenSanja SädevirtaYou ZhouBrandon KayserAshfaq AliLinda AhonenSusanna LallukkaVéronique PellouxMelania GagginiChing JianAntti HakkarainenNina LundbomHelena GyllingAnne SalonenMatej OrešičTuulia HyötyläinenMarju Orho-MelanderAila RissanenFrancesco RubinoKarine ClémentLeanne HodsonHannele Yki-JärvinenPublished in: Diabetes care (2018)
Macronutrient composition of excess energy influences pathways of IHTG: CARB increases DNL, while SAT increases and UNSAT decreases lipolysis. SAT induced the greatest increase in IHTG, insulin resistance, and harmful ceramides. Decreased intakes of SAT could be beneficial in reducing IHTG and the associated risk of diabetes.