Protective, repairing and fibrinolytic effects of rivaroxaban on vascular endothelium.
Ezequiel ÁlvarezBeatriz Paradela-DobarroSergio Raposeiras-RoubínJosé Ramón González-JuanateyPublished in: British journal of clinical pharmacology (2017)
Rivaroxaban enhanced viability, growth and migration of HUVEC, mainly by u-PA activation and upregulation, which also participate in the rivaroxaban-induced fibrinolytic activity at endothelial level. Rivaroxaban also protected from the pro-inflammatory effects of FXa on HUVEC. Altogether may improve endothelial functionality and could contribute to the cardiovascular benefits of rivaroxaban.