Protective, repairing and fibrinolytic effects of rivaroxaban on vascular endothelium.

Ezequiel ÁlvarezBeatriz Paradela-DobarroSergio Raposeiras-RoubínJosé Ramón González-Juanatey

Published in: British journal of clinical pharmacology (2017)

Rivaroxaban enhanced viability, growth and migration of HUVEC, mainly by u-PA activation and upregulation, which also participate in the rivaroxaban-induced fibrinolytic activity at endothelial level. Rivaroxaban also protected from the pro-inflammatory effects of FXa on HUVEC. Altogether may improve endothelial functionality and could contribute to the cardiovascular benefits of rivaroxaban.

Keyphrases

venous thromboembolism
atrial fibrillation
pulmonary embolism
endothelial cells
nitric oxide
poor prognosis
cell proliferation
oxidative stress
diabetic rats