Are redox changes a critical switch for mitotic progression?

Daniel C Lim Vladimir Joukov Micheal B Yaffe

Published in: Molecular & cellular oncology (2020)

Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy.

Keyphrases

cell cycle
cell proliferation
electron transfer
induced apoptosis
fluorescent probe
living cells
cell cycle arrest
transcription factor
amino acid
hydrogen peroxide
cancer therapy
tyrosine kinase
protein kinase
nitric oxide
protein protein
binding protein
signaling pathway