Enhanced Costimulatory Signaling Improves CAR T-cell Effector Responses in CLL.
McKensie A CollinsIn-Young JungZiran ZhaoKimberly ApodacaWeimin KongStefan LundhJoseph A FraiettaArnon P KaterClare SunAdrian WiestnerJan Joseph MelenhorstPublished in: Cancer research communications (2022)
CLL cells insufficiently activate CAR T cells, driven by low levels of costimulatory molecules on the tumor. LN-derived CLL cells are more costimulatory and mediate enhanced CAR T-cell killing. This costimulatory phenotype can be modeled via CD40 L activation, and the activated tumor promotes stronger CAR T-cell responses.