Jan Joseph Melenhorst (J Joseph Melenhorst, Jan J Melenhorst)

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 20

Top Venues

Blood advances

Cancer immunology research

Nature

Science translational medicine

University of Pennsylvania

Universiteit Leiden Faculteit der Wiskunde en Natuurwetenschappen (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Pennsylvania

United States

Director, PDCS :: Pathology & Laboratory Medicine

University of Pennsylvania

United States

Deputy Director, CVPF :: Pathology & Laboratory Medicine

National Institutes of Health

United States

Staff scientist :: Hematology

Education History

Universiteit Leiden Faculteit der Wiskunde en Natuurwetenschappen

Netherlands

PHD :: Hematology

Radboud University Nijmegen

Netherlands

MSC

Moller Institute Tilburg

Netherlands

BSC

Publications

Céline Grégoire, Beatriz Coutinho de Oliveira, Paolo F Caimi, Jo Caers, Jan Joseph Melenhorst
Chimeric antigen receptor T-cell therapy for haematological malignancies: Insights from fundamental and translational research to bedside practice. British journal of haematology (2024)
Jaco A C van Bruggen, Fleur S Peters, Morris Mes, Joanne M Rietveld, Elisa Cerretani, Gaspard Cretenet, Roel van Kampen, Aldo Jongejan, Perry D Moerland, Jan Joseph Melenhorst, Gerritje J W van der Windt, Eric Eldering, Arnon P Kater
T-cell dysfunction in CLL is mediated through expression of Siglec-10 ligands CD24 and CD52 on CLL cells. Blood advances 8 (17) (2024)
Jaco A C van Bruggen, Fleur S Peters, Morris Mes, Joanne M Rietveld, Elisa Cerretani, Gaspard Cretenet, Roel van Kampen, Aldo Jongejan, Perry D Moerland, Jan Joseph Melenhorst, Gerritje J W van der Windt, Eric Eldering, Arnon P Kater
T-cell dysfunction in CLL is mediated through expression of Siglec-10 ligands CD24 and CD52 on CLL cells. Blood advances 8 (17) (2024)
Paolo F Caimi, Jan Joseph Melenhorst
Allogeneic CAR T Cells: Complex Cellular Therapy Designs Test the Limits of Our Preclinical Models. Cancer immunology research 12 (4) (2024)
Jaco A C van Bruggen, Fleur S Peters, Morris Jorden Mes, Joanne M Rietveld, Elisa Cerretani, Gaspard Cretenet, Roel J W van Kampen, Aldo Jongejan, Perry D D Moerland, Jan Joseph Melenhorst, Eric Eldering, Arnon P Kater
T-cell dysfunction in CLL is mediated through expression of SIGLEC-10 ligands CD24 and CD52 on CLL cells. Blood advances (2024)
Meraj H Khan, Jan Joseph Melenhorst
Positively charged patches: tonic for CAR fitness. Cell research (2023)
Gregory M Chen, Jan Joseph Melenhorst, Kai Tan
B cell targeting in CAR T cell therapy: Side effect or driver of CAR T cell function? Science translational medicine 14 (650) (2022)
Caroline Diorio, Rawan Shraim, Regina M Myers, Edward M Behrens, Scott W Canna, Hamid Bassiri, Richard Aplenc, Chakkapong Burudpakdee, Fang Chen, Amanda M DiNofia, Saar Gill, Vanessa Gonzalez, Michele P Lambert, Allison Barz Leahy, Bruce L Levine, Robert B Lindell, Shannon L Maude, Jan Joseph Melenhorst, Haley M Newman, Jessica Perazzelli, Alix E Seif, Simon F Lacey, Carl H June, David M Barrett, Stephan A Grupp, David Trent Teachey
Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell-Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (17) (2022)
Arnon P Kater, Jan Joseph Melenhorst
Do CARs finally hit the CLL road? Blood 139 (12) (2022)
Saar Gill, Vanessa Vides, Noelle V Frey, Elizabeth O Hexner, Susan Metzger, Megan O'Brien, Wei-Ting Hwang, Jennifer L Brogdon, Megan M Davis, Joseph A Fraietta, Avery L Gaymon, Whitney L Gladney, Simon F Lacey, Anne Lamontagne, Anthony R Mato, Marcela V Maus, Jan Joseph Melenhorst, Edward Pequignot, Marco Ruella, Maksim Shestov, John C Byrd, Stephen J Schuster, Donald L Siegel, Bruce L Levine, Carl H June, David L Porter
Anti-CD19 CAR T cells in combination with ibrutinib for the treatment of chronic lymphocytic leukemia. Blood advances 6 (21) (2022)
Jan Joseph Melenhorst, Gregory M Chen, Meng Wang, David L Porter, Changya Chen, McKensie A Collins, Peng Gao, Shovik Bandyopadhyay, Hongxing Sun, Ziran Zhao, Stefan Lundh, Iulian Pruteanu-Malinici, Christopher L Nobles, Sayantan Maji, Noelle V Frey, Saar I Gill, Alison W Loren, Lifeng Tian, Irina Kulikovskaya, Minnal Gupta, David E Ambrose, Megan M Davis, Joseph A Fraietta, Jennifer L Brogdon, Regina M Young, Anne Chew, Bruce L Levine, Donald L Siegel, Cécile Alanio, E John Wherry, Frederic D Bushman, Simon F Lacey, Kai Tan, Carl H June
Decade-long leukaemia remissions with persistence of CD4 + CAR T cells. Nature 602 (7897) (2022)
Jan Joseph Melenhorst, Gregory M Chen, Meng Wang, David L Porter, Changya Chen, McKensie A Collins, Peng Gao, Shovik Bandyopadhyay, Hongxing Sun, Ziran Zhao, Stefan Lundh, Iulian Pruteanu-Malinici, Christopher L Nobles, Sayantan Maji, Noelle V Frey, Saar I Gill, Alison W Loren, Lifeng Tian, Irina Kulikovskaya, Minnal Gupta, David E Ambrose, Megan M Davis, Joseph A Fraietta, Jennifer L Brogdon, Regina M Young, Anne Chew, Bruce L Levine, Donald L Siegel, Cécile Alanio, E John Wherry, Frederic D Bushman, Simon F Lacey, Kai Tan, Carl H June
Author Correction: Decade-long leukaemia remissions with persistence of CD4 + CAR T cells. Nature (2022)
Zhiliang Bai, Steven Woodhouse, Ziran Zhao, Rahul Arya, Kiya W Govek, Dongjoo Kim, Stefan Lundh, Alev Baysoy, Hongxing Sun, Yanxiang Deng, Yang Xiao, David M Barrett, Regina M Myers, Stephan A Grupp, Carl H June, Rong Fan, Pablo G Cámara, Jan Joseph Melenhorst
Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL. Science advances 8 (23) (2022)
Kavita M Dhodapkar, Adam David Cohen, Akhilesh Kaushal, Alfred L Garfall, Renee Julia Manalo, Allison R Carr, Samuel S McCachren, Edward A Stadtmauer, Simon F Lacey, Jan Joseph Melenhorst, Carl H June, Michael C Milone, Madhav V Dhodapkar
Changes in Bone Marrow Tumor and Immune Cells Correlate with Durability of Remissions Following BCMA CAR T Therapy in Myeloma. Blood cancer discovery 3 (6) (2022)
McKensie A Collins, In-Young Jung, Ziran Zhao, Kimberly Apodaca, Weimin Kong, Stefan Lundh, Joseph A Fraietta, Arnon P Kater, Clare Sun, Adrian Wiestner, Jan Joseph Melenhorst
Enhanced Costimulatory Signaling Improves CAR T-cell Effector Responses in CLL. Cancer research communications 2 (9) (2022)
Ziran Zhao, Jan Joseph Melenhorst
Adaptable Leukemia Cells Resisting CAR T-cell Attack via B-cell Activation. Cancer immunology research 10 (9) (2022)
Stefan Lundh, Sayantan Maji, Jan Joseph Melenhorst
Next-generation CAR T cells to overcome current drawbacks. International journal of hematology 114 (5) (2020)
Saba Ghassemi, Selene Nunez-Cruz, Roddy S O'Connor, Joseph A Fraietta, Prachi R Patel, John Scholler, David M Barrett, Stefan M Lundh, Megan M Davis, Felipe Bedoya, Changfeng Zhang, John Leferovich, Simon F Lacey, Bruce L Levine, Stephan A Grupp, Carl H June, Jan Joseph Melenhorst, Michael C Milone
Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells. Cancer immunology research 6 (9) (2018)
Donald M O'Rourke, Mac Lean P Nasrallah, Arati S Desai, Jan Joseph Melenhorst, Keith G Mansfield, Jennifer J D Morrissette, Maria Martinez-Lage, Steven Brem, Eileen Maloney, Angela Shen, Randi Isaacs, Suyash Mohan, Gabriela Plesa, Simon F Lacey, Jean-Marc Navenot, Zhaohui Zheng, Bruce L Levine, Hideho Okada, Carl H June, Jennifer L Brogdon, Marcela V Maus
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Science translational medicine 9 (399) (2018)
Joseph A Fraietta, Kyle A Beckwith, Prachi R Patel, Marco Ruella, Zhaohui Zheng, David M Barrett, Simon F Lacey, Jan Joseph Melenhorst, Shannon E McGettigan, Danielle R Cook, Changfeng Zhang, Jun Xu, Priscilla Do, Jessica Hulitt, Sagar B Kudchodkar, Alexandria P Cogdill, Saar I Gill, David L Porter, Jennifer A Woyach, Meixiao Long, Amy J Johnson, Kami Maddocks, Natarajan Muthusamy, Bruce L Levine, Carl H June, John C Byrd, Marcela V Maus
Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia. Blood 127 (9) (2016)

Jan Joseph Melenhorst.css-eqlu8i{font-size:small;padding-left:4px;} (J Joseph Melenhorst, Jan J Melenhorst)

Publication Activity (10 Years)

Top Topics

Top Venues

Jan Joseph Melenhorst (J Joseph Melenhorst, Jan J Melenhorst)