From Diagnosis to Prognosis: Revisiting the Meaning of Muscle ISG15 Overexpression in Juvenile Inflammatory Myopathies.
Cyrielle HouChloé DurrlemanBaptiste PeriouChristine BarneriasChristine BodemerIsabelle DesguerrePierre QuartierIsabelle MelkiGillian I RiceMathieu P RoderoMathieu Paul RoderoFréderic RelaixBrigitte Bader-MeunierFrançoisJérôme AuthierCyril GitiauxPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Muscle ISG15 expression is strongly associated with juvenile DM, with patients exhibiting a different ISG-15 muscle signature according to their MSA class. Patients with juvenile DM who are positive for MDA-5 have higher expression of ISG15 in both gene form and protein form compared to the other subgroups. Moreover, our data show that negative regulation of type I IFN correlates with milder muscle involvement.
Keyphrases
- skeletal muscle
- poor prognosis
- end stage renal disease
- binding protein
- newly diagnosed
- peritoneal dialysis
- cell proliferation
- oxidative stress
- immune response
- dendritic cells
- prognostic factors
- insulin resistance
- type diabetes
- transcription factor
- gene expression
- copy number
- glycemic control
- metabolic syndrome
- protein protein
- small molecule
- signaling pathway
- cell death
- palliative care
- genome wide
- dna methylation