Phase I Trial of Trametinib with Neoadjuvant Chemoradiation in Patients with Locally Advanced Rectal Cancer.

Christina WuTerence M WilliamsRyan RobbAmy WebbLai Wei Hui-Zi ChenSameh MikhailKristen K CiomborDana Backlund CardinCynthia TimmersSomashekar G Krishna Mark ArnoldAlan HarzmanSherif Abdel-MisihSameek RoychowdhuryTanios Bekaii-SaabEvan Wuthrick

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

The combination of trametinib with 5-FU CRT is safe and well tolerated, and may warrant additional study in a phase II trial, perhaps in a RAS/RAF-mutant selected population.

Keyphrases

rectal cancer
locally advanced
neoadjuvant chemotherapy
phase ii study
squamous cell carcinoma
radiation therapy
wild type
clinical trial
study protocol
phase iii
randomized controlled trial
heart failure
left ventricular
placebo controlled