Decreased expression of S100A8/A9 in V30M related ATTRv amyloidosis.

João MoreiraSofia MartinsMargarida SaraivaMaria João Saraiva

Published in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2023)

The presence of TTRV30M impacts S100 expression, possibly contributing to the impaired immune activation of Schwann cells in nerves from ATTRV30M patients. This may be linked to the diminished immune cellular infiltration in these nerves, contributing in this way for the neuronal dysfunction present in the disease.

Keyphrases

poor prognosis
ejection fraction
induced apoptosis
newly diagnosed
prognostic factors
binding protein
cell cycle arrest
long non coding rna
cell death
patient reported outcomes
multiple myeloma
patient reported
subarachnoid hemorrhage