Defining and Targeting Esophagogastric Cancer Genomic Subsets With Patient-Derived Xenografts.

Ryan H Moy Henry S Walch Marissa S Mattar Walid K Chatila Daniela Molena Vivian E StrongLaura H TangSteven B MaronDaniel G CoitDavid R JonesJaclyn F HechtmanDavid B Solit Nikolaus SchultzElisa de StanchinaYelena Y Janjigian

Published in: JCO precision oncology (2022)

The Memorial Sloan Kettering Cancer Center PDX collection recapitulates the heterogeneity of esophagogastric cancer and is a powerful resource to investigate mechanisms driving tumor progression, identify predictive biomarkers, and develop therapeutic strategies for molecularly defined subsets of esophagogastric cancer.

Keyphrases

papillary thyroid
squamous cell
gene expression
squamous cell carcinoma
drug delivery
single cell
poor prognosis
copy number