Adverse Effects of Low-Dose Methotrexate in a Randomized Double-Blind Placebo-Controlled Trial: Adjudicated Hematologic and Skin Cancer Outcomes in the Cardiovascular Inflammation Reduction Trial.
Kathleen M M VanniNancy BerlinerNina P PaynterRobert J GlynnJean MacFadyenJoshua CollsFengxin LuChang XuPaul M RidkerDaniel H SolomonPublished in: ACR open rheumatology (2020)
Among subjects using LD-MTX, simultaneous two-line cytopenias and pancytopenia were uncommon. We found more cases of skin cancer, particularly squamous cell carcinomas, in the LD-MTX arm than the placebo arm.