Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.

Tomoko TakiguchiHisashi KoideHidekazu NaganoAkitoshi NakayamaMasanori FujimotoAi TamuraEri KomaiAkina ShigaTakashi KonoSeiichiro HiguchiIkki SakumaNaoko HashimotoSawako SuzukiYui MiyabayashiNorio IshiwatariKentaro HoriguchiYukio NakataniKoutaro YokoteTomoaki Tanaka

Published in: BMC endocrine disorders (2017)

Here we described a case of a pituitary tumor diagnosed with acromegaly associated with SCD. We performed quantitative-expression analyses of transcriptional factors of the tumor tissue and immunohistochemistry analysis of tumor-derived primary culture cells, which suggested that the multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells caused acromegaly associated with SCD.

Keyphrases

induced apoptosis
cell cycle arrest
growth hormone
endoplasmic reticulum stress
gene expression
poor prognosis
signaling pathway
high resolution
oxidative stress
transcription factor
cell proliferation