PharmVar GeneFocus: CYP2D6.

Charity Nofziger Amy J TurnerKatrin SangkuhlMichelle Whirl-Carrillo José A G Agúndez John L Black Henry M DunnenbergerGualberto RuanoMartin Alexander KennedyMichael S PhillipsHouda HachadTeri E KleinAndrea Gaedigk

Published in: Clinical pharmacology and therapeutics (2019)

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the information provided by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Keyphrases

endothelial cells
healthcare
primary care
emergency department
genome wide
adverse drug
gene expression
transcription factor
clinical decision support