Adipose Stem Cells in Modern-Day Ophthalmology.
Mutali MusaMarco ZeppieriEhimare S EnaholoCarlo SalatiPier Camillo ParodiPublished in: Clinics and practice (2023)
Stem cells (SCs) have evolved as an interesting and viable factor in ophthalmologic patient care in the past decades. SCs have been classified as either embryonic, mesenchymal, tissue-specific, or induced pluripotent cells. Multiple novel management techniques and clinical trials have been established to date. While available publications are predominantly animal-model-based, significant material is derived from human studies and case-selected scenarios. This possibility of explanting cells from viable tissue to regenerate/repair damaged tissue points to an exciting future of therapeutic options in all fields of medicine, and ophthalmology is surely not left out. Adipose tissue obtained from lipo-aspirates has been shown to produce mesenchymal SCs that are potentially useful in different body parts, including the oculo-visual system. An overview of the anatomy, physiology, and extraction process for adipose-tissue-derived stem cells (ADSC) is important for better understanding the potential therapeutic benefits. This review examines published data on ADSCs in immune-modulatory, therapeutic, and regenerative treatments. We also look at the future of ADSC applications for ophthalmic patient care. The adverse effects of this relatively novel therapy are also discussed.
Keyphrases
- stem cells
- adipose tissue
- clinical trial
- insulin resistance
- cell therapy
- high fat diet
- endothelial cells
- current status
- induced apoptosis
- artificial intelligence
- climate change
- cell cycle arrest
- type diabetes
- randomized controlled trial
- bone marrow
- cell death
- mesenchymal stem cells
- emergency department
- drug induced
- induced pluripotent stem cells
- cataract surgery
- metabolic syndrome
- systematic review
- endoplasmic reticulum stress
- study protocol
- signaling pathway
- case control
- open label
- deep learning
- smoking cessation
- replacement therapy
- placebo controlled