Randomized Controlled Trials in Lung, Gastrointestinal, and Breast Cancers: An Overview of Global Research Activity.
J Connor WellsAdam FundytusShubham SharmaWilma M HopmanJoseph C Del PaggioBishal GyawaliDeborah A MukherjiNazik HammadConjeevaram S PrameshAjay AggarwalRichard SullivanChristopher M BoothPublished in: Current oncology (Toronto, Ont.) (2022)
Important differences in RCT design and output exist between the three major cancer sites. Use of surrogate endpoints and the magnitude of benefit associated with new treatments vary substantially across cancer sites.