Targeting synovial lymphatic function as a novel therapeutic intervention for age-related osteoarthritis in mice.

Xi LinRichard D BellSarah E CathelineTakahiro TakanoAndrew McDavidJennifer H JonasonEdward M SchwarzLianping Xing

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

SLS function is reduced in aged knees due to decreased VEGF-C/VEGFR3 signaling. VEGF-C treatment attenuates osteoarthritic joint damage and improves synovial lymphatic drainage in aged mice. The SLS and VEGF-C/VEGFR3 signaling represent novel physio-pathological mechanisms and therapeutic targets for age-related osteoarthritis.

Keyphrases

vascular endothelial growth factor
endothelial cells
high fat diet induced
lymph node
rheumatoid arthritis
randomized controlled trial
knee osteoarthritis
oxidative stress
wild type
adipose tissue
combination therapy
metabolic syndrome
replacement therapy