Demethylation by low-dose 5-aza-2'-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma.

Cécile DesjobertArnaud CarrierAudrey DelmasDiego M MarzeseAntoine DaunayFlorence BusatoArnaud PillonJörg TostJoëlle RiondGilles FavreChantal EtievantPaola Barbara Arimondo

Published in: Clinical epigenetics (2019)

Thus, our data suggest that epigenetic- and/or miR-based therapeutic strategies can be relevant to limit metastatic dissemination of melanoma.

Keyphrases

low dose
long non coding rna
cell proliferation
poor prognosis
skin cancer
long noncoding rna
squamous cell carcinoma
small cell lung cancer
dna methylation
gene expression
high dose
electronic health record
cell migration
binding protein