Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE).
Aline TalhoukJoshy GeorgeChen WangTimothy BuddenTuan-Zea TanDerek S ChiuStefan KommossHuei San LeongStephanie ChenMaria P IntermaggioBlake GilksTayyebeh M NazeranMila VolchekWafaa ElatreRex C BentleyJanine SenzAmy LumVeronica ChowHanwei SudderuddinRobertson MackenzieSamuel C Y LeongGeyi LiuDustin JohnsonBilly ChenAocs GroupJennifer AlsopSusana N BanerjeeSabine BehrensClara BodelonAlison H BrandLouise A BrintonMichael E CarneyYoke-Eng ChiewKara L Cushing-HaugenCezary CybulskiDarren EnnisSian FeredayRenée Turzanski FortnerJesús García-DonasAleksandra Gentry-MaharajRosalind M GlasspoolTeodora GoranovaCasey S GreenePaul HaluskaHolly R HarrisJoy HendleyBrenda Y HernandezEsther HerpelMercedes Jimenez-LinanChloe KarpinskyjScott H KaufmannGary L KeeneyCatherine J KennedyMartin KoebelJennifer M KoziakMelissa C LarsonJenny LesterLiz-Anne LewsleyJolanta LissowskaJan LubińskiHugh LukGeoff MacintyreSven MahnerIain A McNeishJanusz MenkiszakNikilyn NevinsAna OsorioOleg OszurekJosé PalaciosSamantha HinsleyCeleste L PearceMalcolm C PikeAnna M PiskorzIsabelle Ray-CoquardValerie RheniusCristina Rodríguez-AntonaRaghwa SharmaMark E ShermanDilrini De SilvaNaveena SinghHans-Peter SinnDennis SlamonHonglin SongHelen SteedEuan A StronachPamela J ThompsonAleksandra TołoczkoBritton TrabertNadia TraficanteChiu-Chen TsengMartin WidschwendterLynne R WilkensStacey J WinhamBoris WinterhoffAlicia Beeghly-FadielJavier BenitezAndrew BerchuckJames D BrentonRobert BrownJenny Chang-ClaudeGeorgia Chenevix-TrenchAnna De FazioPeter Andreas FaschingMaría J GarcíaSimon A GaytherMarc T GoodmanJacek GronwaldMichelle J HendersonBeth Y KarlanLinda E KelemenUsha MenonSandra OrsulicPaul David Peter PharoahNicolas WentzensenAnna H WuJoellen M SchildkrautMary Anne RossingGottfried E KonecnyDavid G HuntsmanRuby Yun-Ju HuangEllen L GoodeSusan J RamusJennifer Anne DohertyDavid D BowtellMichael S AnglesioPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
We validated the PrOTYPE assay following the Institute of Medicine guidelines for the development of omics-based tests. This fully defined and locked-down clinical grade assay will enable trial design with molecular subtype stratification and allow for objective assessment of the predictive value of HGSOC molecular subtypes in precision medicine applications.See related commentary by McMullen et al., p. 5271.