Epigenetic dysregulation-mediated COL12A1 upregulation predicts worse outcome in intrahepatic cholangiocarcinoma patients.

Zengwei TangYuan YangQi ZhangTingbo Liang

Published in: Clinical epigenetics (2023)

Promoter hypermethylation-induced miR-424-5p downregulation contributes to COL12A1 upregulation in iCCA. COL12A1 is a promising druggable target for epigenetic therapy of iCCA.

Keyphrases

dna methylation
gene expression
cell proliferation
end stage renal disease
signaling pathway
poor prognosis
ejection fraction
chronic kidney disease
newly diagnosed
high glucose
transcription factor
oxidative stress
drug induced
bone marrow
patient reported
replacement therapy