PAPP-A2 deficiency does not exacerbate the phenotype of a mouse model of intrauterine growth restriction.

Julian K ChristiansKendra I LennieMaria F Huicochea MunozNimrat Binning

Published in: Reproductive biology and endocrinology : RB&E (2018)

Effects of Mmp9 deficiency were not exacerbated by the deletion of Pappa2. Our results do not provide evidence that upregulation of placental PAPP-A2 represents a mechanism to compensate for impaired fetal growth.

Keyphrases

mouse model
replacement therapy
poor prognosis
cell proliferation
signaling pathway
smoking cessation