Role of airway smooth muscle cell phenotypes in airway tone and obstruction in guinea pig asthma model.
Mayra D Álvarez-SantosMarisol Álvarez-GonzálezElizabeth Eslava-De-JesusAngel González-LópezIvonne Pacheco-AlbaYazmín Pérez-Del-ValleRodrigo Rojas-MadridBlanca Bazán-PerkinsPublished in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2022)
Our data suggest that each type of AO and airway tone depends on different ASM phenotypes: direct and indirect AO seems to be sensitive to the level of oxidative stress; indirect obstruction induced by antigen appears to be influenced by the expression of TGF-β1 and the SERCA2b expression level plays a role in the airway tone.