Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids.
Koos de WitUlrich H W BeuersAnna MukhaEdwin StigterM Can GulersonmezJose M Ramos PittolSabine MiddendorpR Bart TakkenbergSaskia W C van MilPublished in: Liver international : official journal of the International Association for the Study of the Liver (2022)
Rifaximin - after uptake into enterocytes - stimulates intracellular nitrogen detoxification by PXR-independent mechanisms. Active apical excretion of rifaximin by ABCB1 into the intestinal lumen explains its low systemic bioavailability. Our study implies that rifaximin, next to modulation of the microbiome, has direct effects on ammonia scavenging in the human small intestinal epithelium.