Cancer Cachexia and Related Metabolic Dysfunction.
Guilherme Wesley Peixoto da FonsecaJerneja FarkasEva DoraStephan von HaehlingMitja LainscakPublished in: International journal of molecular sciences (2020)
Cancer cachexia is a complex multifactorial syndrome marked by a continuous depletion of skeletal muscle mass associated, in some cases, with a reduction in fat mass. It is irreversible by nutritional support alone and affects up to 74% of patients with cancer-dependent on the underlying type of cancer-and is associated with physical function impairment, reduced response to cancer-related therapy, and higher mortality. Organs, like muscle, adipose tissue, and liver, play an important role in the progression of cancer cachexia by exacerbating the pro- and anti-inflammatory response initially activated by the tumor and the immune system of the host. Moreover, this metabolic dysfunction is produced by alterations in glucose, lipids, and protein metabolism that, when maintained chronically, may lead to the loss of skeletal muscle and adipose tissue. Although a couple of drugs have yielded positive results in increasing lean body mass with limited impact on physical function, a single therapy has not lead to effective treatment of this condition. Therefore, a multimodal intervention, including pharmacological agents, nutritional support, and physical exercise, may be a reasonable approach for future studies to better understand and prevent the wasting of body compartments in patients with cancer cachexia.
Keyphrases
- adipose tissue
- papillary thyroid
- skeletal muscle
- inflammatory response
- squamous cell
- insulin resistance
- randomized controlled trial
- type diabetes
- high fat diet
- squamous cell carcinoma
- cardiovascular disease
- stem cells
- metabolic syndrome
- coronary artery disease
- young adults
- bone marrow
- chronic pain
- toll like receptor
- case report
- pain management
- body composition
- cell therapy
- lps induced
- anti inflammatory
- glycemic control