Three-dimensional experiments and individual based simulations show that cell proliferation drives melanoma nest formation in human skin tissue.
Parvathi HaridasAlexander P BrowningJacqui A McGovernD L Sean McElwainMatthew J SimpsonPublished in: BMC systems biology (2018)
Nest size depends on cell number, and is driven primarily by cell proliferation rather than cell migration. All experimental results are consistent with simulation data from a 3D individual based model (IBM) of cell migration and cell proliferation.