miR-29b-3p targetedly regulates VEGF to inhibit tumor progression and cisplatin resistance through Nrf2/HO-1 signaling pathway in non-small cell lung cancer.
Zhen SunMingming RenJieting NiuGuojie TangYanguang LiFanyi KongXiang SongPublished in: Environmental toxicology (2024)
Our findings indicate that miR-29b-3p impedes NSCLC cells' biological behaviors and augments their sensitivity to cisplatin by targeting VEGF to modulate the Nfr2/HO-1 signaling pathway.
Keyphrases
- pi k akt
- signaling pathway
- cell cycle arrest
- induced apoptosis
- vascular endothelial growth factor
- endothelial cells
- oxidative stress
- small cell lung cancer
- epithelial mesenchymal transition
- cell proliferation
- endoplasmic reticulum stress
- poor prognosis
- advanced non small cell lung cancer
- brain metastases
- tyrosine kinase