Impact of rs174537 on Critically Ill Patients with Acute Lung Injury: A Secondary Analysis of the OMEGA Randomized Clinical Trial.

Beverly DossoCharlotte Mae K WaitsKelli N SimmsSusan SergeantD Clark FilesTimothy D HowardCarl D LangefeldFloyd H ChiltonElaheh Rahbar

Published in: Current developments in nutrition (2020)

This study highlights the importance of genetic and racial contributions to PUFA metabolism and inflammation. In particular, rs174537 had a significant impact on circulating DHA and urinary isoprostane concentrations. Given our relatively small sample size, further investigations in larger multiethnic cohorts are needed to evaluate the impact of rs174537 on fatty acid metabolism and downstream inflammation.

Keyphrases

fatty acid
oxidative stress
lps induced
genome wide
clinical trial
african american
dna methylation
gene expression
copy number
double blind