Nitric Oxide Decreases Acute Kidney Injury and Stage 3 Chronic Kidney Disease after Cardiac Surgery.

Chong LeiLorenzo BerraEmanuele RezoagliBinglan YuHailong DongShiqiang YuLihong HouMin ChenWensheng ChenHongbing WangQijun ZhengJie ShenZhenxiao JinTao ChenRong ZhaoEmily ChristieVenkata S SabbisettiFrancesco NordioJoseph V BonventreLize XiongWarren M Zapol

Published in: American journal of respiratory and critical care medicine (2019)

In patients undergoing multiple valve replacement and prolonged cardiopulmonary bypass, administration of nitric oxide decreased the incidence of acute kidney injury, transition to stage 3 chronic kidney disease, and major adverse kidney events at 30 days, 90 days, and 1 year. Clinical trial registered with ClinicalTrials.gov (NCT01802619).

Keyphrases

acute kidney injury
nitric oxide
chronic kidney disease
end stage renal disease
clinical trial
cardiac surgery
patients undergoing
nitric oxide synthase
hydrogen peroxide
aortic valve
mitral valve
risk factors
randomized controlled trial
coronary artery disease
study protocol
emergency department
double blind