Red blood cell exchange in patients with sickle cell disease-indications and management: a review and consensus report by the therapeutic apheresis subsection of the AABB.
Elizabeth BillerYong ZhaoMary BergLisa BoggioKelley E CapocelliDeanna C FangScott KoepsellLejla Music-AplencHuy P PhamAngela TremlJohn WeissGeoffrey WoolBeverly W BaronPublished in: Transfusion (2019)
Although a consensus as to protocol details may not be possible, there are areas of agreement in the management of these patients, for example, that it is optimal to avoid hyperviscosity and iron overload, that a target Hb S level in the range of 30% is generally desirable, and that RCE as an acute treatment for pain crisis in the absence of other acute or chronic conditions is ordinarily discouraged.
Keyphrases
- sickle cell disease
- red blood cell
- liver failure
- end stage renal disease
- respiratory failure
- drug induced
- newly diagnosed
- ejection fraction
- chronic kidney disease
- chronic pain
- public health
- randomized controlled trial
- aortic dissection
- prognostic factors
- clinical practice
- hepatitis b virus
- intensive care unit
- spinal cord
- replacement therapy
- patient reported
- smoking cessation